Depot-specific mRNA modifications in fat cells and obesity; significance of mRNA modifications in human fat cells for metabolic complications of obesity

Obesity is one of the major health burdens. Intra-abdominal fat storage strongly increases the risk of obesity-associated metabolic complications. These comorbidities further stresses the health care systems enormously. We have designed a research project using adipose tissue/adipocytes aiming to understand mechanisms contributing to developing obesity-related conditions. We hypothesize that RNA methylation (m6A) is adipose tissue depot specific.

​We reported differences in gene expression/methylation between human adipose tissue depots. These data add weight to the hypothesis that distinct molecular mechanisms in fat depots contribute to the observed clinical consequences. We hypothesize that RNA modifications may be fat depot specific and may play an important role in establishing fat depot specific gene expression. We perform m6Aseq and expect specific patterns that translate into depot-specificity. 

Collaborators

Gunnar Mellgren, Johan Fernø.
University of Bergen, Haukeland Hospital, Norway.

Tom Mala, Jon Kristinsson.
Aker Hospital, Oslo, Norway.

Housheng Hansen He.
University of Toronto, Canada.

Matthias Blüher.
University of Leipzig, Germany.

Geir Slupphaug, Cathrine B. Vågbø.
NTNU Trondheim, Norway

Funding

Helse Sør-Øst

Results

Ongoing

Project leader

Yvonne Böttcher 

Project participant

Torunn Rønningen

Time frame

Project start: 01.08.2018
Project end: 31.07.2021

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