We have designed a research project using adipose tissue/adipocytes aiming to understand mechanisms contributing to developing obesity-related conditions. We hypothesize that chromatin accessibility is adipose tissue depot specific.
We reported differences in gene expression/methylation between human adipose tissue depots. These data add weight to the hypothesis that distinct molecular mechanisms in fat depots contribute to the observed clinical consequences. We hypothesize that open chromatin accessibility may be fat depot specific and is important in establishing fat depot specific gene expression. We perform ATACseq and expect specific patterns that translate into depot-specificity.
Jøran Hjelmesæth, Jens K. Hertel.
Morbid Obesity Center Tønsberg, Norway
Gunnar Mellgren, Johan Fernø.
University of Bergen, Haukeland Hospital, Norway
University of Leipzig, Germany
Lars la Cour Poulsen
Project start: 1.10.2017. Project end: 30.09.2020